If you have never had a blood clot, you do not need treatment with blood thinners. There are 2 copies for Factor V gene, which are passed down from our parents. Vitamin K is necessary for making the proteins that aid in blood clotting, according to the Harvard T.H. Do you know someone who has suffered a deep vein thrombosis, pulmonary embolism, or other type of venous blood clot? Prothrombin Gene Mutation (Factor II) - Cleveland Clinic Symptoms and causes - Mayo Clinic All rights reserved. Inherited thrombophilias in pregnancy. 0000007474 00000 n Its important to talk to your provider about any concerns you have related to life expectancy or future complications. Are young and healthy when you get a clot. Hormones and birth control pills also increase womens risk of blood clots. Accessed June 4, 2018. But the plan would have to be modified to make it appropriate if you have these or other conditions. If you smoke, consider the benefits of quitting. When anticoagulants are prescribed, a prothrombin time (PT) test is used to evaluate its effectiveness. Whole grains: Choose whole grains like whole-grain bread, quinoa, farro and brown rice rather than refined grains, such as white bread, white rice, crackers and baked goods made with white flour. Want to talk about Multiple Myeloma: Anyone else? She maintains a focus on anxiety disorders and depression and aims to explore other areas of mental health including dissociative disorders such as maladaptive daydreaming. The risk increases with age: Having 1 Factor V Leiden gene (heterozygous type) slightly increases the chance of developing a blood clot. Green tea in high amounts could reduce PT-INR values. Doctors generally prescribe blood-thinning medications to treat people who develop abnormal blood clots. How experienced is the lab at performing this test? 5-Factor Diet Plan Review: What You Eat & More - WebMD This may not be a good choice for those who have to travel a lot for work, have an inflexible schedule, or prefer to eat out, as food prep and timing may be a problem. Factor V and other proteins work together to help your blood clot when necessary. Tips on transitioning to a whole food fertility diet. Factor V Leiden (pronounced factor five) is the most common hereditary clotting disorder in the United States, present in 2 percent to 7 percent of Caucasians, less often in Hispanics and. Where's the Health Benefit? This change causes factor V to resist the actions of other proteins (protein C and protein S), which normally inactivate factor V when needed to keep your blood from clotting abnormally. What will a positive or negative result tell me? small children have a risk of 1 in 100,000 per year, those in their twenties have a risk of 1 in 10,000 per year, by age 40, this risk is 1 in 1,000 per year. In your body, you have 100% of Factor V Leiden and no normal Factor V. This happens in less than 1 out of 100 people. Some clots do no damage and disappear on their own. If you have Factor V Leiden, you have a greater chance of developing blood clots. Lockwood CJ, et al. That's important because high blood pressure can damage blood vessels, increasing blood clot risk. Stand up and walk around during long flights. Factor V Leiden is the most common inherited condition causing increased blood clotting. We use cookies to enhance your experience. Recurrent fetal loss during the second or third trimester suggests an inherited thrombophilia or antiphospholipid antibody. Each 5-Factor five-ingredient meal must include all five must-have food groups: The 5-Factor Diet doesnt mention alcohol specifically, but on the diets cheat day you may eat or drink anything you like. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. However, most people with this genetic mutation never develop these complications. (accessed March 04, 2023). You might have heard that "you can't choose your family," and the same applies to the genes you inherit from them. If signs and symptoms do occur, they can include: Known as a pulmonary embolism, this occurs when a portion of a DVT breaks free and travels through the right side of your heart to your lung, where it blocks blood flow. Accessed June 4, 2018. Cleveland Clinic is a non-profit academic medical center. (https://www.heart.org/en/health-topics/venous-thromboembolism/prevention-and-treatment-of-excessive-blood-clotting-hypercoagulation), (https://www.redcrossblood.org/donate-blood/how-to-donate/eligibility-requirements/eligibility-criteria-alphabetical.html), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). This gene carries instructions that tell your body how to properly create the factor V protein. You must do the 25-minute 5-Factor workout five days a week. Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. Regular noncontact exercise, such as walking or swimming, is still recommended for good health. Factor V Leiden Information for Patients and Families Factor V Leiden is a blood clotting disorder. <]>> If you cant walk around, flex your ankles and point your toes up and down. Women have a greater chance of developing a blood clot during pregnancy. Most people with factor V Leiden never develop abnormal clots. Fewer than 1 in 100 people of Asian descent. Vitamin K is found in the following foods: Flaxseed may inhibit the proper absorption of anticoagulants. About 1 out of 10,000 people will develop a DVT or PE each year. Prothrombin G20210A (Factor II Mutation) Resources. Keeping your intake of vitamin K at a even level will help maintain your blood thinners (especially warfarin) levels. These blood clots can be life-threatening. Factor V Deficiency Vs. About 1 of every 250 Black people in America has the prothrombin gene mutation. Lean protein: Prioritize lean proteins such as chicken, turkey and lean beef. Two components of the plan, lower GI foods and smaller, more frequent meals, are both known to keep the blood sugar at a lower level, but the amount of carbohydrates would have to be tailored to your own diabetes treatment plan. Middeldorp S, Coppens M. Hereditary Thrombophilia. Blood clots in the deep veins in your legs (called deep vein thrombosis or DVT) or in your lungs (called pulmonary embolus or PE) can be dangerous. In general, you should avoid: You can help lower your risk of blood clots with lifestyle changes, including: Visit your provider for a yearly checkup. Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). The disorder is most common in people who are white and of European descent. Its important to go to all of your appointments and talk to your provider about any questions or concerns you have. How to Build a Healthy Diet When You Have Factor V Leiden For factor V Leiden, some basic questions to ask your doctor include: If your doctor recommends genetic testing, some questions you might want to ask the genetic specialist include: Connect with others like you for support and answers to your questions in the Blood Cancers & Disorders support group on Mayo Clinic Connect, a patient community. If I have children, do they need to be tested? Talk to your provider to see if you should be taking a blood thinner. The sooner you receive care, the better your chances of a good outcome. Creator and celebrity fitness trainer Harley Pasternak says it's a lifestyle plan, not a diet. What are my treatment options if a mutation is found? Accessed June 4, 2018. (On the contrary, these are all heart-healthy foods.). Inheriting one copy slightly increases your risk of developing blood clots. 0000001440 00000 n 0 These conditions can be life-threatening and require immediate medical treatment. Advertising on our site helps support our mission. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2018. If you have this gene mutation, factor V is slow to turn off, and this can create a larger-than-needed clot, which could break off and start traveling through your body. Yes, those living with factor v Leiden should avoid any foods that contain a high level of vitamin K. (Green leafy vegetables are a big one). Accessed June 4, 2018. As a result, your blood may clot more easily than it should, leading to serious complications. It has been suggested as a risk factor for RPL as it triggers thrombophilia and impairs the initial vascularization process at implantation [ 6 ]. The two most common hereditary thrombophilia conditions are the factor V Leiden and prothrombin 20210 gene mutations, both of which have been the subject of previous Cardiology Patient Pages. The Association Between MTHFR C677T Gene Polymorphism and Repeated A single copy of these materials may be reprinted for noncommercial personal use only. 4. Tenderness or pain in your leg or arm, which you may only feel when standing or moving around. Does my factor V Leiden need to be treated? Factor V Leiden (FAK-tur five LIDE-n) is a mutation of one of the clotting factors in the blood. If you know you have the factor V gene mutation, you can work to make your body an inhospitable place for clots, starting with something under your control: your diet. Accessed June 4, 2018. If you get the mutation from one of your parents, you are heterozygous (you have only one abnormal copy of the Factor II gene, but the gene from your other parent is normal). THE DOCTORS COULD NOT FIGURE OUT WHERE MY BLOOD CLOTS WERE COMING FROM SINCE I DID NOT HAVE ANY DVT'S. National Heart, Lung, and Blood Institute. Harvard T.H. Anticoagulant Food-Drug Interactions. ", cdc.gov: "How much physical activity do adults need?". (https://pubmed.ncbi.nlm.nih.gov/34540419/), (https://www.genome.gov/Genetic-Disorders/Factor-V-Leiden-Thrombophilia), (https://medlineplus.gov/lab-tests/coagulation-factor-tests/), (https://medlineplus.gov/genetics/gene/f5/), Visitation, mask requirements and COVID-19 information, Heart, Vascular & Thoracic Institute (Miller Family). Usually, once the clot is formed, factor V is "turned off," but not in those with factor V Leiden. As a result, clotting goes on longer than usual. Our mission of spreading lifesaving #bloodclot awareness is possible thanks to the generous support of our partners. PDF Factor V Leiden - Blood Clots Otherwise, all your meals should be limited to dishes made with foods from the five must-have groups mentioned above. If youre having a deep vein thrombosis or pulmonary embolism, your provider will typically treat you with anticoagulants (blood thinners) and occasionally with thrombolytic (clot-busting) medicines. .wpcdt-timer-24806 {background-color: #aaaaaa;}.wpcdt-timer-24806 .wpcdt-title, .wpcdt-timer-24806 .wpcdt-desc, .wpcdt-timer-24806 .wpcdt-desc p{color: #b81d32;}.wpcdt-timer-24806 .wpcdt-clock-circle h4, Ask your provider for resources to, Limit alcohol intake, and avoid it during long flights (it can lead to, Move around more. Your body has many different proteins that do this work. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits, It is advised that vitamin K intake through diet (chiefly through liver meats, high amounts of green leafy vegetables, and cranberry juice) also be closely monitored in such patients for the same reason. You won't go hungry on The 5-Factor Diet. A genetic mutation (change) causes factor V Leiden. .wpcdt-timer-24806 .wpcdt-clock .wpcdt-digits span{color: #ffffff;}.wpcdt-timer-24806 .wpcdt-clock{max-width: 640px;}, Carol McIntosh of Caroga Lake, New York was 32 when she was diagnosed with her first incident of deep vein, March is Blood Clot Awareness Month (BCAM), a time dedicated to spreading the word about blood clots and their potentially. Guide To Managing Factor V Leiden - HealthPrep.com If you are experiencing serious medical symptoms, please see the You may be treated with blood thinners until the risk has passed. Want to talk about Multiple Myeloma: Anyone else? About 1 of every 250 Black people in America has the prothrombin gene mutation. For instance, they may work faster or slower, more or less effectively, or cause digestive problems. https://www.uptodate.com/contents/search. The liver is responsible for breaking down alcohol and some medications, and this may cause a slower than normal metabolism of the anticoagulant, increasing the drug concentration in the blood, and hence the risk of bleeding. In: Williams Hematology. National Library of Medicines list This can be a life-threatening situation. Factor V Leiden: Care Instructions - Alberta Avoidance of alcohol-containing beverages during long flights. Each part of the plan revolves around the number five. You will most likely not have a dangerous blood clot, but your provider can provide counseling on how to reduce the risk of a deep vein thrombosis or pulmonary embolism. Factor V Leiden makes you more likely to develop: Its important to know that people with factor V Leiden wont necessarily develop DVT or PE. If your provider feels its warranted, theyll order blood tests, including: Simply having a family history of blood clots may not be reason enough to run these tests. Get useful, helpful and relevant health + wellness information. Wear compression stockings if your provider prescribes them for you. Did I get the mutation from both parents or just one? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Mayo Clinic is a not-for-profit organization. Up to 1 in 50 people who are Black, Hispanic or Native American. If you are heterozygous, theres a 50% chance that your children will get the mutation. Being able to have a day when you can enjoy any food you want is a big plus, too. What information will come out of the test?